The Binding of Isaac: Four Souls Wiki
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Pills! are a set of Loot Cards in The Binding of Isaac: Four Souls.

Effects[]

All pill cards have you perform a dice roll. All pill cards have 3 different effects. Most of them use a formula that goes:

  • 1 - 2 : Positive effect
  • 3 - 4 : Positive effect
  • 5 - 6 : Negative effect

There are also some pills which have their 5 - 6 result be good in certain situations.

The Pills[]

There are multiple pill cards in the game. Some are exclusive to the Expansion Packs.

In the Base Game[]

Blue Pills

  • 1 - 2 : Loot 1
  • 3 - 4 : Loot 3
  • 5 - 6 : Discard 1 Loot

Red Pills

  • 1 - 2 : +1 Damage till the end of turn
  • 3 - 4 : +1 Health till the end of turn
  • 5 - 6 : Take 1 Damage

Yellow Pills

  • 1 - 2 : Gain 4 Coins
  • 3 - 4 : Gain 7 Coins
  • 5 - 6 : Lose 4 Coins

Kickstarter Expansion Exclusives[]

Purple Pills

  • 1 - 2 : Recharge all of your Items
  • 3 - 4 : +1 To All of your dice Rolls till the end of turn
  • 5 - 6 : -2 To All of your dice Rolls till the end of turn

Four Souls+ Expansion Exclusives[]

Black Pills

  • 1 - 2 : Deal 1 Damage to a player
  • 3 - 4 : Deal 1 Damage to an active Monster
  • 5 - 6 : Take 1 Damage

White Pills

  • 1 - 2 : Cancel the effect of any Loot Card being played
  • 3 - 4 : All other players discard a Loot Card
  • 5 - 6 : Nothing

Yellow Spotted Pills

  • 1 - 2 : Reroll one of your items
  • 3 - 4 : Reroll any item
  • 5 - 6 : Reroll all of your items

Strategies[]

  • All pill cards become a lot more useful if you have any sort of roll manipulation like Book of Belial or P.H.D.
  • The Blue or Yellow pills can be played if you don't have that much Loot or Coins to lose.
  • Purple Pills could be played to purposely raise or lower your dice roll.
  • You can activate any on hit items by rolling a 5 or 6 with the Red and Black pills.
  • Rerolling all of your items using the Yellow Spotted pills may not always be a bad option.

Gallery[]

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