The Binding of Isaac: Four Souls Wiki

This article is a stub. You can help The Binding of Isaac: Four Souls Wiki by expanding it.

Play an additional loot card this turn.
This can be done on any player's turn in response to any action.
Hit points 2
Damage 1
Starting item Blood Lust

Samson is a playable character in The Binding of Isaac: Four Souls.


Samson's ability is quite powerful as it can be used both to quickly kill monsters and collect their rewards for himself, and stop other players from killing or even attempting to kill monsters. If your house rules allow for bargaining, then it can even be used as a money generating tool by extorting attackers into paying you not to Blood Lust their targets. Samson should seek to quickly get items that increase either his rolls, like Synthoil, or give him health, like Breakfast. Skeleton Key is also very strong on him, as he can mow through monsters with his ability as long as he can keep attacking.

Instead of using Blood Lust to boost yourself, you can compile as many passive items that make you better at combat and save Blood Lust for using it on monsters to kill your opponent. Additionally, getting the Left Hand to recharge Blood Lust and be able to possibly kill a player every turn.

Additional notes[]

  • Samson was a reward for completing "The Basement" challenge during the Kickstarter campaign

    The list of challenges for The Basement